A risk discussion starts with the known hazards.
Ibogaine has been associated with serious cardiac risk, including changes to cardiac electrical activity that may be relevant to arrhythmia risk. The U.S. Food and Drug Administration has stated that ibogaine is not approved for any medical use in the United States and has warned of potentially life-threatening adverse effects, including cardiac events. Its FDA information on ibogaine is an important starting point for readers assessing safety claims.
Other physiological concerns reported in the literature and advisories include interactions with medications or substances, altered consciousness, vomiting, seizure-related concerns, and the possibility that an underlying condition may not be identified before exposure. Risk is not reducible to a single checklist: dose, co-occurring substance use, medical history, the care environment, and response capacity may all matter.
Public-facing safety language is most useful when it separates established concern, reported practice, and information that remains unverified.